Conducting OIG exclusion screening is vitally important to protect healthcare providers from legal, financial, and reputational harm. Screening employees, vendors, and contractors against the Office of Inspector General’s exclusion list can help providers verify that they are not unknowingly employing or contracting with an individual or entity that is excluded from participating in federally funded health programs like Medicare or Medicaid. Not engaging in this process can lead to significant fines, exclusion from federal programs, and harm to credibility. In addition, conducting OIG exclusion screening will help providers support their regulatory compliance obligations, minimize penalties, and establish a culture of ethical conduct and patient safety.